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SCREENING

Cervical CancerWomen 21 to 65 (Pap Smear) or 30-65 (in combo with HPV testing)

GRADE

Strongly Recommended

SPECIFIC RECOMMENDATIONS

This recommendation statement applies to women who have a cervix, regardless of sexual history. This recommendation statement does not apply to women who have received a diagnosis of a high-grade precancerous cervical lesion or cervical cancer, women with in utero exposure to diethylstilbestrol, or women who are immunocompromised (such as those who are HIV positive). The USPSTF recommends screening for cervical cancer in women age 21 to 65 years with cytology (Pap smear) every 3 years or, for women age 30 to 65 years who want to lengthen the screening interval, screening with a combination of cytology and human papillomavirus (HPV) testing every 5 years.

FREQUENCY OF SERVICE

Screening women age 21 to 65 years every 3 years with cytology provides a reasonable balance between benefits and harms. Among women age 30 to 65 years, HPV testing combined with cytology (co-testing) every 5 years offers a comparable balance of benefits and harms and is therefore a reasonable alternative for women in this age group who would prefer to extend the screening interval.Screening with cytology more often than every 3 years confers little additional benefit, with large increases in harms, including additional procedures and assessment and treatment of transient lesions.

RISK FACTOR INFORMATION

No Risk Factor Information currently available.